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Generic Name: Olanzapine and fluoxetine HCl capsules (SIM-bee-ax)

Drug Class: Treatment of Bipolar Disorder


Drug Uses

SYMBYAX is a prescription medicine used to treat adults who have depression with bipolar disorder. SYMBYAX contains two medicines, olanzapine and fluoxetine hydrochloride. Olanzapine is also the active ingredient in Zyprexa and Zyprexa Zydis . Fluoxetine hydrochloride is also the active ingredient in Prozac , Prozac Weekly , and Sarafem . SYMBYAX has not been studied in children.

General Information

Read the Patient Information that comes with SYMBYAX before you start using it and each time you get a refill. There may be new information. This information does not take the place of talking with your doctor about your medical condition or treatment. It is important to stay under a doctors care while taking SYMBYAX. Do not change or stop treatment without first talking with your doctor. Talk to your doctor or pharmacist if you have any questions about SYMBYAX.

How it Works

It works by helping to restore the balance of certain natural chemicals in the brain. These chemicals are referred to as "neurotransmitters".

How to Take It

Take SYMBYAX exactly as instructed by your doctor. Your doctor will usually start you on a low dose of SYMBYAX. Your dose may be adjusted depending on your body s response to SYMBYAX. Your dose will also depend on certain medical problems you have. Do not stop taking SYMBYAX or change your dose even if you feel better, without talking with your doctor. SYMBYAX is usually taken once a day in the evening. Take SYMBYAX at the same time each day. SYMBYAX may be taken with or without food.

Possible Side Effects



Drug Interactions

Missed Dose

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take only your regularly scheduled dose. Do not take more than your doctor has prescribed for you.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, 59 ' to 86' F (15' to 30' C), and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.


Talk to your doctor if you are pregnant or plan to become pregnant. It is not known if SYMBYAX can harm your unborn baby. You and your doctor should decide if SYMBYAX is right for you during pregnancy. Are breast-feeding or plan to breast-feed. SYMBYAX may pass into your milk and may harm your baby. You should choose either to breast-feed or take SYMBYAX, but not both.

More Information

This leaflet summarizes important information about SYMBYAX. If you would like more information, talk with your doctor. You can ask your doctor or pharmacist for information that is written for health professionals. You can also call 1-800-Lilly-Rx (1-800-545-5979) or visit our website at www.SYMBYAX.com.

Copyright © 2004 PharmClips, Inc. All rights reserved. Information expires March 1, 2005. Published March 1, 2004.

This information is not intended to cover all possible uses, directions, precautions, drug interactions, or adverse effects. This is general information and should not in any event be construed as specific instructions for individual patients. The publisher does not accept any responsibility for the accuracy of the information or the consequences arising from the application, use, or misuse of any of the information contained herein, including any injury and/or damage to any person or property as a matter of product liability, negligence, or otherwise. No warranty, expressed or implied, is made in regard to the contents of this material. The reader is advised to check with their health care provider before making any changes in their drug regimen.
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